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2014年畢業(yè)于蘭州大學(xué)，獲化學(xué)學(xué)士學(xué)位； 2019年畢業(yè)于加拿大阿爾伯塔大學(xué)，獲化學(xué)博士學(xué)位；2019年9月起先后在美國麻省理工學(xué)院和日本東京大學(xué)從事博士后研究； 擬于2025年10月起任中科院分子細(xì)胞科學(xué)卓越創(chuàng)新中心(生物化學(xué)與細(xì)胞生物學(xué)研究所)研究員，研究組長，博士生導(dǎo)師。

細(xì)胞中的分子相互作用，形成信號網(wǎng)絡(luò)以調(diào)節(jié)生物過程。在細(xì)胞中實時地、原位地觀測這些分子信號的變化以及分析它們與細(xì)胞功能的聯(lián)系有助于我們了解生命的運行原理、揭示疾病的發(fā)生機(jī)理。

我們實驗室致力于開發(fā)新型熒光成像工具和熒光成像技術(shù)，以蛋白質(zhì)工程和活體熒光成像為基礎(chǔ)，從時間和空間尺度上探索復(fù)雜生物系統(tǒng)（比如動物大腦）中細(xì)胞內(nèi)以及細(xì)胞間的分子信號傳遞，以及這些分子信號在正常和疾病狀態(tài)下的動態(tài)差異。

當(dāng)前主要研究項目包括：

1. 近紅外熒光蛋白以及近紅外熒光分子探針的開發(fā)與應(yīng)用

2. 新型多重?zé)晒獬上窦夹g(shù)的開發(fā)與應(yīng)用

1. S.F. Shaykevich, J.P. Little, Y.Qian, M.E.Paquet, R.E. Campbell, D. Razansky, S.Shoham, “Multimodal fluorescence-optoacoustic in vivo imaging of the near-infrared calcium ion indicator NIR-GECO2G”, Photoacoustics, 2025, 41,1007.1
2. Y. Qian, O.T.Celiker, Z. Wang, B. Guner-Ataman, E.S.Boyden, “Temporally multiplexed imaging of dynamic signaling networks in living cells”, Cell, 2023, 186, 5656-5672.21.
3. J. Zhang, J. Newman, Z. Wang, Y. Qian, P. Feliciano-Ramos, W. Guo, Z.S. Chen, T. Honda, C. Linghu, R. Etienne-Cummings, E. Fossum, E.S. Boyden, M. Wilson, “Pixel-wise programmability enables dynamic high-SNR cameras for high-speed microscopy” Nature Communications, 2024, 15, 4480.
4. R. Hashizume, H. Fujii, S. Mehta, K. Ota, Y. Qian, W. Zhu, M. Drobizhev, Y. Nasu, J. Zhang, H. Bito, R.E. Campbell, “A genetically encoded far-red fluorescent calcium ion biosensor derived from a biliverdin-binding protein”, Protein Science, 2022, 31, e4440.
5. Y. Qian, D.M.O. Cosio, K.D.Piatkevich, S. Aufmkolk, W.C. Su, O.T. Celiker, A.Schohl, M.H. Murdock, A. Aggarwal, Y.F. Chang, P.W. Wiseman, E.S. Ruthazer, E.S. Boyden, and R.E. Campbell, “Improved genetically encoded near-infrared fluorescent calcium ion indicators for in vivo imaging”, PLOS Biology, 2020, 18, e3000965.
6. Y. Qian*, K.D. Piatkevich*, B. McLarney*, A.S. Abdelfattah, S. Mehta, M.H. Murdock, S. Gottschalk, R.S. Molina, W. Zhang, Y. Chen, J. Wu, M. Drobizhev, T.E. Hughes, J. Zhang, E.R. Schreiter, S. Shoham, D. Razansky, E.S. Boyden, and R.E. Campbell, “A genetically-encoded near-infrared fluorescent calcium ion indicator”, Nature Methods, 2019, 16, 171-174 (*equal contributions).
7. Y. Qian, V. Rancic, J. Wu, K. Ballanyi, and R.E. Campbell, “A bioluminescent Ca²⁺ indicator based on a topological variant of GCaMP6s”, ChemBioChem, 2019, 20, 516-520 (VIP, cover feature).
8. R.S. Molina, Y. Qian, J. Wu, Y. Shen. R.E. Campbell, T.E. Hughes, and M. Drobizhev, “Understanding the Ca²⁺-dependent Fluorescence Change in Red Genetically Encoded Ca²⁺?Indicators”, Biophysical Journal, 2019, 116, 1873-1886?
9. Y. Shen,?S-Y. Wu, V. Rancic,?A. Aggarwal,?Y. Qian, S-I. Miyashita, K. Ballanyi, R.E. Campbell, and M. Dong, “Genetically encoded fluorescent indicators for imaging intracellular potassium ions”,?Communications Biology,?2, 18.
10. J. Wu, A.S. Abdelfattah, H. Zhou, A. Ruangkittisakul, Y. Qian, K. Ballanyi and R.E?? Campbell, “Genetically Encoded Glutamate Indicators with Altered Color and Topology”, ACS Chemical Biology. 2018, 13, 1832-1837.