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首頁 全所PI名錄
  • 豆曉陽
  • 研究員，研究組長，博士生導師
  • E-mail: xiaoyang.dou@sibcb.ac.cn
  • 實驗室主頁: https://doulab.sibcb.ac.cn
    個人簡介：

  • 2011年畢業(yè)于河北經(jīng)貿(mào)大學； 2018年畢業(yè)于中科院計算生物學研究所，獲計算生物學博士學位；2018年12月至2024年6月于芝加哥大學從事博士后研究； 于2024年7月起任中科院分子細胞科學卓越創(chuàng)新中心 (生物化學與細胞生物學研究所) 研究員，研究組長，博士生導師。

    社會任職：
    研究方向：
  • RNA修飾與染色質(zhì)調(diào)控、計算生物學
    研究工作：

  • 非編碼RNA及其化學修飾是基因調(diào)控網(wǎng)絡(luò)中的核心調(diào)節(jié)因子，它們在RNA與蛋白質(zhì)、DNA及其他RNA等生物大分子的相互作用中起著關(guān)鍵作用。這種相互作用對調(diào)節(jié)染色質(zhì)重塑和基因轉(zhuǎn)錄活化至關(guān)重要， 從而影響一系列生物學過程。通過結(jié)合表觀轉(zhuǎn)錄組學、表觀遺傳學、基因組學和計算生物學等交叉學科的優(yōu)勢，采用干濕實驗相結(jié)合的研究方法，我們將：

    （1）深入探索非編碼RNA及其化學修飾在染色質(zhì)重塑和基因轉(zhuǎn)錄活化中的調(diào)控模式、機制和生物學功能。

    （2）解析非編碼RNA及其化學修飾在神經(jīng)退行性疾病和癌癥等人類重大疾病中異常代謝的成因與后果，及其在免疫治療中的作用與機制。

    （3）通過數(shù)據(jù)整合和深度數(shù)據(jù)挖掘，研究非編碼RNA的命運決定模式。

    我們的研究目標是深化對具有調(diào)控功能的非編碼RNA及其化學修飾的理解，拓展其應(yīng)用潛力，為疾病的預(yù)防、診斷和治療提供新的分子靶點和策略。歡迎加入我們！

    承擔科研項目情況：
    代表論著：
    1. Dou, X.*, Xiao, Y. *, Shen, C. *, Wang, K. *, Wu, T., Liu, C., Li, Y., Yu, X., Liu, J., Dai, Q., Pajdzik, K., Ye, C., Ge, R., Gao, B., Yu, J., Sun, S., Chen, M., Chen, J., & He, C. (2023). RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation.?Nature Cell Biology,?25(9), 1359–1368.?
    2. Li, Y. *, Dou, X. *, Liu, J. *, Xiao, Y. *, Zhang, Z., Hayes, L., Wu, R., Fu, X., Ye, Y., Yang, B., Ostrow, L. W., He, C., & Sun, S. (2023). Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration.?Nature Neuroscience,?26(8), 1328–1338.
    3. Wang, L.*, Dou, X.*, Chen, S.*, Yu, X., Huang, X., Zhang, L., Chen, Y., Wang, J., Yang, K., Bugno, J., Pitroda, S., Ding, X., Piffko, A., Si, W., Chen, C., Jiang, H., Zhou, B., Chmura, S. J., Luo, C., Liang, H. L., … Weichselbaum, R. R. (2023). YTHDF2 inhibition potentiates radiotherapy antitumor efficacy.?Cancer Cell,?41(7), 1294–1308.e8.
    4. Dou, X.*, Huang, L.*, Xiao, Y.*, Liu, C., Li, Y., Zhang, X., Yu, L., Zhao, R., Yang, L., Chen, C., Yu, X., Gao, B., Qi, M., Gao, Y., Shen, B., Sun, S., He, C., & Liu, J. (2023). METTL14 is a chromatin regulator independent of its RNA N6-methyladenosine methyltransferase activity.?Protein & Cell,?14(9), 683–697.
    5. He, P. C.*, Wei, J.*, Dou, X.*, Harada, B. T., Zhang, Z., Ge, R., Liu, C., Zhang, L. S., Yu, X., Wang, S., Lyu, R., Zou, Z., Chen, M., & He, C. (2023). Exon architecture controls mRNA m6A suppression and gene expression.?Science,?379(6633), 677–682.?
    6. Liu, J.*, Dou, X.*, Chen, C.*, Chen, C., Liu, C., Xu, M. M., Zhao, S., Shen, B., Gao, Y., Han, D., & He, C. (2020).?N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription.?Science,?367(6477), 580–586.?
    7. Dou, X.*, Boyd-Kirkup, J. D.*, McDermott, J.*, Zhang, X.*, Li, F., Rong, B., Zhang, R., Miao, B., Chen, P., Cheng, H., Xue, J., Bennett, D., Wong, J., Lan, F., & Han, J. J. (2019). The strand-biased mitochondrial DNA methylome and its regulation by DNMT3A.?Genome Research,?29(10), 1622–1634.
    8. Green, C. D.*, Huang, Y.*, Dou, X.*, Yang, L., Liu, Y., & Han, J. J. (2017). Impact of Dietary Interventions on Noncoding RNA Networks and mRNAs Encoding Chromatin-Related Factors.?Cell Reports,?18(12), 2957–2968.
    9. Guo, J., Zou, Z., Dou, X., Zhao, X., Wang, Y., Wei, L., Pi, Y., Wang, Y., He, C., & Guo, S. (2024). Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior.?Nucleic Acids Research, gkae093.?
    10. Wu, T., Cheng, A. Y., Zhang, Y., Xu, J., Wu, J., Wen, L., Li, X., Liu, B., Dou, X., Wang, P., Zhang, L., Fei, J., Li, J., Ouyang, Z., & He, C. (2024). KARR-seq reveals cellular higher-order RNA structures and RNA-RNA interactions.?Nature Biotechnology, 10.1038/s41587-023-02109-8.?
    11. Xiao, Y., Chen, Y. M., Zou, Z., Ye, C., Dou, X., Wu, J., Liu, C., Liu, S., Yan, H., Wang, P., Zeng, T. B., Liu, Q., Fei, J., Tang, W., & He, C. (2024). Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing.?Nature Methods,?21(2), 247–258.
    12. Wang, L., Si, W., Yu, X., Piffko, A., Dou, X., Ding, X., Bugno, J., Yang, K., Wen, C., Zhang, L., Chen, D., Huang, X., Wang, J., Arina, A., Pitroda, S., Chmura, S. J., He, C., Liang, H. L., & Weichselbaum, R. (2023). Epitranscriptional regulation of TGF-β pseudoreceptor BAMBI by m6A/YTHDF2 drives extrinsic radioresistance.?The Journal of Clinical Investigation,?133(24), e172919.
    13. Zhang, L., Dou, X., Zheng, Z., Ye, C., Lu, T. X., Liang, H. L., Wang, L., Weichselbaum, R. R., & He, C. (2023). YTHDF2/m6?A/NF-κB axis controls anti-tumor immunity by regulating intratumoral Tregs.?The EMBO Journal,?42(15), e113126.
    14. Dai, Q., Zhang, L. S., Sun, H. L., Pajdzik, K., Yang, L., Ye, C., Ju, C. W., Liu, S., Wang, Y., Zheng, Z., Zhang, L., Harada, B. T., Dou, X., Irkliyenko, I., Feng, X., Zhang, W., Pan, T., & He, C. (2023). Quantitative sequencing using BID-seq uncovers abundant pseudouridines in mammalian mRNA at base resolution.?Nature Biotechnology,?41(3), 344–354.
    15. Chokkalla, A. K., Pajdzik, K., Dou, X., Dai, Q., Mehta, S. L., Arruri, V., & Vemuganti, R. (2023). Dysregulation of the Epitranscriptomic Mark m1A in Ischemic Stroke.?Translational Stroke Research,?14(6), 806–810.
    16. Wei, J., Yu, X., Yang, L., Liu, X., Gao, B., Huang, B., Dou, X., Liu, J., Zou, Z., Cui, X. L., Zhang, L. S., Zhao, X., Liu, Q., He, P. C., Sepich-Poore, C., Zhong, N., Liu, W., Li, Y., Kou, X., Zhao, Y., … He, C. (2022). FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development.?Science,?376(6596), 968–973.
    17. Chen, C., Liu, W., Guo, J., Liu, Y., Liu, X., Liu, J., Dou, X., Le, R., Huang, Y., Li, C., Yang, L., Kou, X., Zhao, Y., Wu, Y., Chen, J., Wang, H., Shen, B., Gao, Y., & Gao, S. (2021). Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos.?Protein & Cell,?12(6), 455–474.
    18. Hao, Z., Wu, T., Cui, X., Zhu, P., Tan, C., Dou, X., Hsu, K. W., Lin, Y. T., Peng, P. H., Zhang, L. S., Gao, Y., Hu, L., Sun, H. L., Zhu, A., Liu, J., Wu, K. J., & He, C. (2020). N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA.?Molecular Cell,?78(3), 382–395.e8.
    19. Liu, C., Cui, X., Zhao, B. S., Narkhede, P., Gao, Y., Liu, J., Dou, X., Dai, Q., Zhang, L. S., & He, C. (2020). DNA 5-Methylcytosine-Specific Amplification and Sequencing.?Journal of the American Chemical Society,?142(10), 4539–4543.
    20. Cheng, H.*, Dou, X.*, & Han, J. D. (2016). Understanding super-enhancers.?Science China. Life Sciences,?59(3), 277–280.
    21. Liu, P., Dou, X., Liu, C., Wang, L., Xing, C., Peng, G., Chen, J., Yu, F., Qiao, Y., Song, L., Wu, Y., Yue, C., Li, J., Han, J. D., Tang, K., & Jing, N. (2015). Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate.?Nature Communications,?6, 6830.
    獲獎及榮譽：
    研究組成員：