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　2012年畢業(yè)于華中科技大學(xué)，獲生物信息技術(shù)學(xué)士學(xué)位;2017年畢業(yè)于中科院生物物理研究所，獲生物信息學(xué)博士學(xué)位;2018至2022年于美國(guó)國(guó)家癌癥研究中心從事博士后研究;于2022年7月起任中科院分子細(xì)胞科學(xué)卓越創(chuàng)新中心(生物化學(xué)與細(xì)胞生物學(xué)研究所)研究員，研究組長(zhǎng)，博士生導(dǎo)師

　　基因組DNA生物遺傳信息的重要載體，維持其穩(wěn)定性和準(zhǔn)確性是一切生命活動(dòng)的基礎(chǔ)。除UV射線等外源性刺激之外，細(xì)胞在正常生命代謝活動(dòng)中會(huì)發(fā)生內(nèi)源的程序性DNA損傷，包括起始減數(shù)分裂同源重組所需的DNA雙鏈斷裂;TET家族蛋白介導(dǎo)的主動(dòng)去甲基化過(guò)程所需的DNA單鏈斷裂;適應(yīng)性免疫中起始基因重排、高頻突變、DNA重組等過(guò)程以產(chǎn)生抗體多樣性的DNA損傷等。程序性損傷通常受到細(xì)胞精密地調(diào)控以保證遺傳信息的完整。然而，如果這些損傷在修復(fù)過(guò)程中發(fā)生錯(cuò)誤，例如DNA雙鏈斷裂的一端錯(cuò)誤地連接到不同染色體斷裂的另一端時(shí)會(huì)導(dǎo)致易位，則可能促進(jìn)癌癥等疾病的發(fā)生和影響疾病治療效果。

　　與此同時(shí)，細(xì)胞內(nèi)也存在著大量?jī)?nèi)源的非程序性損傷，例如DNA復(fù)制過(guò)程中產(chǎn)生的堿基錯(cuò)配，核苷酸的氧化、烷化、脫氨基化這些異常修飾等?；蚪M上大量遍布的短串聯(lián)重復(fù)序列(Short Tandem Repeat, STR)也是一個(gè)非常重要的非程序損傷來(lái)源。STR由1-6個(gè)核苷酸通過(guò)重復(fù)排列組成。根據(jù)重復(fù)序列的不同，STR可以在RNA轉(zhuǎn)錄和DNA復(fù)制等過(guò)程中形成G四聯(lián)體(G-quadruplex)、三鏈DNA(Triplex DNA)、十字架(cruciform)等二級(jí)結(jié)構(gòu)，而這些結(jié)構(gòu)極易引起基因組不穩(wěn)定。

　　我們將利用已開(kāi)發(fā)的用于檢測(cè)DNA斷裂和修復(fù)過(guò)程的高通量測(cè)序技術(shù)，結(jié)合生物信息學(xué)分析方法及分子生物學(xué)等多學(xué)科技術(shù)手段研究不同類(lèi)型內(nèi)源性損傷在腫瘤中的影響，包括(但不限于)以下幾個(gè)方向：1)神經(jīng)細(xì)胞內(nèi)的程序性DNA損傷與化療引起的神經(jīng)損傷之間的關(guān)聯(lián)。2)短重復(fù)序列引起的基因組不穩(wěn)定對(duì)腫瘤發(fā)生、進(jìn)展的影響。

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