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首頁 全所PI名錄
  • 王廣川
  • 研究員，研究組長，博士生導(dǎo)師
  • E-mail: guangchuan.wang@sibcb.ac.cn
  • 實(shí)驗室主頁: 
    個人簡介：

  • 2013年獲浙江大學(xué)博士學(xué)位;2013—2016年擔(dān)任浙江大學(xué)求是高等研究院講師;2016—2021年在美國耶魯大學(xué)醫(yī)學(xué)院從事博士后研究, 獲Rudolph J Anderson fellowship和CRI Irvington Postdoctoral fellowship資助; 2021年1月起擔(dān)任中科院分子細(xì)胞科學(xué)卓越創(chuàng)新中心(生化與細(xì)胞所)研究員、研究組長、博士生導(dǎo)師。

    社會任職：
  •  
    研究方向：
  • 腫瘤免疫逃逸機(jī)制和免疫治療
    研究工作：

  • 　　在腫瘤發(fā)展和轉(zhuǎn)移過程中，腫瘤細(xì)胞通過基因突變塑造的微環(huán)境是其逃逸免疫監(jiān)視和免疫治療的關(guān)鍵。利用CRISPR基因編輯和高通量篩選技術(shù)剖析腫瘤微環(huán)境中，對于腫瘤免疫逃逸和免疫治療應(yīng)答具有關(guān)鍵調(diào)控作用的免疫細(xì)胞亞群和分子，旨在發(fā)現(xiàn)新的免疫治療靶標(biāo)。研究組還將進(jìn)一步探索如何將上述免疫治療靶標(biāo)與T細(xì)胞療法或溶瘤病毒療法結(jié)合起來，開發(fā)新型免疫療法。

    承擔(dān)科研項目情況：
    代表論著：
    1. Wang G,*  Chow RD,* Zhu L,* Bai Z,* Ye L, Zhang F, Renauer PA, Dong MB, Dai X, Zhang X, Du Y, Cheng Y, Niu L, Chu Z, Kim K, Liao C, Clark P, Errami Y, and Chen S. CRISPR-GEMM pooled mutagenic screening identifies KMT2D as a major modulator of immune checkpoint blockade. Cancer Discovery 2020 Dec;10(12):1912-1933. (*equal contribution)
    2. Wang G,* Chow RD,* Bai Z, Zhu L, Errami Y, Dai X, Dong M, Ye L, Zhang X, Renauer PA, Park JJ, Shen L, Ye H, Fuchs CS, and Chen S. Multiplexed activation of endogenous genes by CRISPRa elicits potent anti-tumor immunity. Nature Immunology 2019, 20: 1494–1505. (*equal contribution)
    3. Dong MB,* Wang G,* Chow RD,* Ye L,* Zhu L, Dai X, Park JJ, Kim HR, Errami Y, Guzman CD, Zhou X, Chen K, Renauer PA, Du Y, Shen J, Lam S, Zhou J, Lannin DR, Herbst RS, Chen S. Systematic identification of immunotherapy targets using genome-scale in vivo CRISPR screens in CD8+ cytotoxic T cells. Cell 2019, 178(5):1189-204. (*equal contribution)
    4. Chow RD,* Wang G,* Ye L,* Codina A, Kim HR, Shen L, Dong MB, Errami Y, Chen S. In vivo profiling of metastatic double knockouts through CRISPR-Cpf1 screens. Nature Methods. 2019, 16(5):405-408. (*equal contribution)
    5. Codina A,* Renauer PA,* Wang G,* Chow RD,* Park JJ, Ye H, Zhang K, Dong MD, Gassaway B, Ye L, Errami Y, Shen L, Chang A, Jain D, Herbst RS, Bosenberg M, Rinehart J, Fan R, Chen S. Convergent identification and interrogation of tumor-intrinsic factors that modulate cancer immunity in vivo. Cell Systems. 2019, 8(2):136-151.e7. (*equal contribution)
    6. Wang G,* Chow RD,* Ye L, Guzman CD, Dai X, Dong MB, Zhang F, Sharp PA, Platt RJ, and Chen S. Mapping a Functional Cancer Genome Atlas of Tumor Suppressors in Mouse Liver Using AAV-CRISPR Mediated Direct in vivo Screening. Science Advances. 2018, 4: eaao5508. (*equal contribution)
    7. Chow RD,* Guzman CD,* Wang G,* Schmidt F,# Youngblood MW, Ye L, Errami Y, Dong MB, Martinez MA, Zhang S, Renauer P, Bilguvar K, Gunel M, Sharp PA, Zhang F, Platt RJ, Chen S. AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma. Nature Neuroscience. 2017, 20(10):1329-1341. (*equal contribution)
    8. Wang G, Zhou H, Nian Q-G, Yang Y, Qin C-F, Tang R. Robust vaccine formulation produced by assembling a hybrid coating of polyethyleneimine–silica. Chemical Science 2016, 7: 1753-1759.
    9. Wang G, Wang H-J, Zhou H, Nian Q-G, Song Z, Deng Y-Q, Wang X, Zhu S-Y, Li X-F, Qin C-F, Tang R. Hydrated silica exterior produced by biomimetic silicification confers viral vaccine heat-resistance. ACS Nano 2015, 9(1): 799-808.
    10. Wang G, Cao R-Y, Chen R, Mo L, Han J-F, Wang X, Xu X, Jiang T, Deng Y-Q, Lyu K, Zhu S-Y, Qin E-D, Tang R, Qin C-F. Rational design of thermostable vaccines by engineered peptide-induced virus self-biomineralization under physiological conditions. Proc Natl Acad Sci USA 2013, 110(19): 7619-7624.
    11. Wang G, Li X, Mo L, Song Z, Chen W, Deng Y, Zhao H, Qin E, Qin C, Tang R. Eggshell-Inspired Biomineralization Generates Vaccines that Do Not Require Refrigeration. Angew Chem Int Ed 2012, 51(42): 10576-10579.
    12. Wang G, Wang L, Liu P, Yan Y, Xu X, Tang R. Extracellular silica nanocoat confers thermotolerance on individual cells: a case study of material-based functionalization of living cells. ChemBioChem 2010, 11(17): 2368-2373.
    13. Zhou H,* Wang G,* Li XF, Li Y, Zhu SY, Qin CF, Tang R. Alumina-encapsulated vaccine formulation with improved thermostability and immunogenicity. Chem Commun 2016, 52(38):6447-50. (*equal contribution)
    14. Wang B,* Wang G,* Zhao B, Chen J, Zhang X, Tang R. Antigenic-sheltering universal red blood cells by polydopamine-based cell superficial-engineering. Chemical Science 2014, 5: 3463-3468. (*equal contribution)
    獲獎及榮譽(yù)：
    研究組成員：