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首頁(yè) 全所PI名錄
  • 朱學(xué)良
  • 研究員，研究組長(zhǎng)，博士生導(dǎo)師
  • E-mail: xlzhu@@sibcb.ac.cn
  • 實(shí)驗(yàn)室主頁(yè): 
    個(gè)人簡(jiǎn)介：

  • 　　1985年畢業(yè)于中國(guó)科技大學(xué)生物系，1988年在該校獲碩士學(xué)位并留校任教。1990年底赴美，以聯(lián)合培養(yǎng)方式先后在加州大學(xué)圣地亞哥分校和德州大學(xué)圣安東尼奧健康科學(xué)中心完成博士論文，1994年底回到中國(guó)科大，1995年在中科院上海細(xì)胞所獲博士學(xué)位。同年成為中科院上海生命科學(xué)研究中心的博士后并任課題組長(zhǎng)。1997年被聘為研究組長(zhǎng)，副研究員，1999年晉升研究員，博士生導(dǎo)師，同年轉(zhuǎn)入中科院上海生命科學(xué)研究院生化與細(xì)胞所。

    　　2001年獲國(guó)家“杰出青年基金”支持，國(guó)家基金委“創(chuàng)新研究群體”學(xué)術(shù)帶頭人、科技部“重大研究計(jì)劃”首席科學(xué)家。歷任所長(zhǎng)助理、副所長(zhǎng)、所學(xué)術(shù)委員會(huì)主任、所學(xué)位委員會(huì)主席、中科院分子細(xì)胞生物學(xué)重點(diǎn)實(shí)驗(yàn)室主任、中國(guó)細(xì)胞生物學(xué)會(huì)副理事長(zhǎng)等職?，F(xiàn)任Mol Biol Cell和《細(xì)胞生物學(xué)雜志》副主編、Cell Res編委、Faculty of 1000的Faculty成員、中國(guó)細(xì)胞生物學(xué)會(huì)監(jiān)事等。

    　　作為(共同)通訊作者在Cell、Nat Cell Biol、Dev Cell、EMBO J、J Cell Biol、 Cell Rep、 EMBO Rep等雜志發(fā)表多篇研究論文。獲上海市“自然科學(xué)牡丹獎(jiǎng)”、上海市自然科學(xué)獎(jiǎng)“一等獎(jiǎng)”、“上海領(lǐng)軍人才”、第六屆“談家楨生命科學(xué)創(chuàng)新獎(jiǎng)”、中國(guó)細(xì)胞生物學(xué)學(xué)會(huì)-CST“杰出成就獎(jiǎng)”、全國(guó)優(yōu)秀科技工作者，并多次獲得中科院“優(yōu)秀教師”、“優(yōu)秀研究生指導(dǎo)教師”等榮譽(yù)。


    社會(huì)任職：
    研究方向：
  • 細(xì)胞周期與運(yùn)動(dòng)
    研究工作：

  • ?????? 細(xì)胞周期與細(xì)胞運(yùn)動(dòng)都是生命最基本的活動(dòng)。細(xì)胞周期的目的即是通過(guò)細(xì)胞分裂完成遺傳物質(zhì)的均等分離和細(xì)胞質(zhì)的分割，實(shí)現(xiàn)細(xì)胞的增殖。而細(xì)胞分裂、遷移、纖毛運(yùn)動(dòng)、胞內(nèi)運(yùn)輸?shù)燃?xì)胞運(yùn)動(dòng)形式以其重要、復(fù)雜、動(dòng)態(tài)和完美展現(xiàn)出強(qiáng)烈的吸引力。我們利用分子生物學(xué)、細(xì)胞生物學(xué)和發(fā)育生物學(xué)的多種技術(shù)和手段，以及細(xì)胞、斑馬魚(yú)、小鼠等系統(tǒng)深入探討細(xì)胞運(yùn)動(dòng)的結(jié)構(gòu)基礎(chǔ)、分子調(diào)節(jié)機(jī)理，及其與干細(xì)胞維持、分化和疾病的關(guān)系。其中涉及細(xì)胞骨架、分子馬達(dá)、中心粒、動(dòng)粒和纖毛等細(xì)胞結(jié)構(gòu)和組分，以及物質(zhì)運(yùn)輸、信號(hào)轉(zhuǎn)導(dǎo)、基因表達(dá)、蛋白質(zhì)修飾和相互作用等過(guò)程。這些豐富的研究?jī)?nèi)容既充滿(mǎn)挑戰(zhàn)又富于情趣，希望每位鐘愛(ài)生命科學(xué)研究的學(xué)子都可從中找到屬于自己的樂(lè)土。
    ???????研究組形成了在工作上緊張嚴(yán)謹(jǐn)，生活上團(tuán)結(jié)活潑的氣氛，并以豐富多彩且富于挑戰(zhàn)性的研究?jī)?nèi)容滿(mǎn)足對(duì)生物科學(xué)的熱愛(ài)、對(duì)科學(xué)新發(fā)現(xiàn)的渴望、和對(duì)自然之美的追求。

    承擔(dān)科研項(xiàng)目情況：
    代表論著：
    1. Ma S#,?Li L#,?Li Z#,?Luo S#,?Liu Q#,?Du W,?Qiu B,?Gui M*,?Zhu X*?&?Guo Q*?(2025).In situ cryo-electron tomography reveals the progressive biogenesis of basal bodies and cilia in mouse ependymal cells. Nat Commun 16:5932
    2. Pan X#, Fang C#, Shen C#, Li X, Xie L, Li L, Huang S, Yan X*,?& Zhu X*(2024). Directional ciliary beats across epithelia require Ccdc57-mediated coupling between axonemal orientation and basal body polarity. Nat Commun 15(1):10249
    3. Chen Q#,? Zhao H#,? Pan X,? Fang C,? Qiu B,? Guo J,? Yan X*,? Zhu X* (2024).A polarized multicomponent foundation upholds ciliary central microtubules, J Mol Cell Biol: mjae031.doi: 10.1093/jmcb/mjae031.
    4. Fang C#, Pan X#, Li D#, Chen W, Huang Y, Chen Y, Li L, Gao Q, Liang X, Li D, Zhu X*, Yan X*(2024). Distinct roles of Kif6 and Kif9 in mammalian ciliary trafficking and motility, J Cell Biol 223(11):e202312060.
    5. Qin Z#, Yue M#, Tang S#, Wu F#, Sun H#, Li Y, Zhang Y, Izumi H, Huang H, Wang W, Xue Y, Tong X, Mori S, Taki T, Goto K, Jin Y, Li F, Li F, Gao Y, Fang Z, Fang Y, Hu L, Yan X, Xu G, Chen H, Kobayashi S, Ventura A, Wong K, Zhu X*,Chen L*, Ren S*, Chen L*,Ji H*(2024). EML4-ALK fusions drive lung adeno-to-squamous transition through JAK-STAT activation. J Exp Med 221(3):e20232028.
    6. Meng X #, Xu C#, Li J#, Qiu B#, Luo J#, Hong Q, Tong Y, Fang C, Feng Y, Ma R, Shi X, Lin C, Pan C, Zhu X*, Yan X*, Cong Y*(2024). Multi-scale structures of the mammalian radial spoke and divergence of axonemal complexes in ependymal cilia. Nat Commun 15(1):362.
    7. Xiao Y#, Chen J#, Yang S, Sun H, Xie L, Li J, Jing N*, and Zhu X*(2022). Maternal mRNA deadenylation and allocation via Rbm14 condensates facilitates vertebrate blastula development. EMBO J e111364. doi: 10.15252/embj.2022111364.
    8. Ren J#, Li D#, Liu J#, Liu H, Yan X, Zhu X*, Feng W*(2022). Intertwined Wdr47-NTD dimer recognizes a basic-helical motif in Camsap proteins for proper central-pair microtubule formation. Cell Rep 41(6):111589.
    9. Qiao C#, Li D#, Liu Y#, Zhang S#, Liu K, Liu C, Guo Y, Jiang T, Fang C, Li N, Zeng Y, He Zhu X,? Lippincott-Schwartz J,? Dai Q*,? Li D*(2022). Rationalized deep learning super-resolution microscopy for sustained live imaging of rapid subcellular processes. Nat Biotechnol doi: 10.1038/s41587-022-01471-3.
    10. Hao K, Zhu X*, Yan X*(2022). Purification and immunostaining of mouse ependymal ciliary shafts. Bio Protoc 12(14):e4467.
    11. Yang S#, Liu C#, Guo Y, Li G, Li D, Yan X, and Zhu X*(2022). Self-construction of actin networks through phase separation-induced abLIM1 condensates. Proc Natl Acad Sci USA 119 (29) e2122420119.
    12. Hao K, Chen Y, Yan X*, and Zhu X*(2021). Cilia locally synthesize proteins to sustain their ultrastructure and functions. Nat Commun 12(1):6971. Featured article
    13. Liu H#, Zheng J#, Zhu L#, Xie L, Chen Y, Zhang Y, Zhang W, Zhou J, Zhu X* and Yan X*(2021). Wdr47, Camsaps, and Katanin cooperate to generate ciliary central microtubules. Nat Commun 12(1):5796.
    14. Zhang Y, Chen Z, Wang F, Sun H, Zhu X*, Ding J*, and Zhang T*(2021). Nde1 is a Rab9 effector for loading late endosomes to cytoplasmic dynein motor complex. Structure S0969-2126(21)00412-3. doi: 10.1016/j.str.2021.10.013.
    15. Qin Z#, Sun H#, Yue M, Pan X, Chen L, Feng X, Yan X*, Zhu X* and Ji H*(2021). Phase separation of EML4-ALK in firing downstream signaling and promoting lung tumorigenesis. Cell Discov 7(1):33.
    16. Zhao H, Chen Q#, Li F, Cui L, Xie L, Huang Q, Liang X, Zhou J, Yan X*, Zhu X*(2021).Fibrogranular materials function as organizers to ensure the fidelity of multiciliary assembly. Nat Commun 12(1):1273.
    17. Zheng W, Li F#, Ding Z, Liu H, Zhu L, Xu C, Li J, Gao Q, Wang Y, Fu Z, Peng C, Yan X*, Zhu X*, Cong Y*(2021).Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM. Proc Natl Acad Sci USA 118?(4)?e2021180118.
    18. Duan S, Li H#, Zhang Y#, Yang S, Chen Y, Qiu B, Huang C, Wang J, Li J, Zhu X*, and Yan X*(2020). Rabl2 GTP hydrolysis licenses BBSome-mediated export to fine-tune ciliary signaling. EMBO J e105499. Cover Story
    19. Li Y, Guo F, Jing Q, Zhu X*, Yan X*(2020). Characterization of centriole biogenesis during multiciliation in planarians. Biol Cell doi: 10.1111/boc.202000045.
    20. Zhao H, Yang S#, Chen Q, Duan X, Li G, Huang Q, Zhu X*, Yan X*(2020). Cep57 and Cep57l1 function redundantly to recruit the Cep63-Cep152 complex for centriole biogenesis. J Cell Sci 133(13):jcs241836.
    21. Chen Y, Zheng J, Li X., Zhu L, Shao Z, Yan X*, and Zhu X*(2020). Wdr47 controls neuronal polarization through the Camsap family microtubule minus-end-binding proteins. Cell Rep. Doi:10.1016/j.celrep.2020.107526.
    22. Xiao Y, Chen J, Wan Y, Gao Q, Jing N, Zheng Y and Zhu X* (2019). Regulation of zebrafish dorsoventral patterning by phase separation of RNA-binding protein Rbm14. Cell Discov 5:37.
    23. Zhao H, Chen Q, Fang C, Huang Q, Zhou J, Yan X* and Zhu X* (2019). Parental centrioles are dispensable for deuterosome formation and function during basal body amplification. EMBO Reports 20(4). pii: e46735.
    24. Zheng J, Liu H, Zhu L, Chen Y, Zhao H, Zhang W, Li F, Xie L,?Yan X* and?Zhu X*(2019). Microtubule-bundling protein Spef1 enables mammalian ciliary central apparatus formation.?J Mol Cell Biol 11(1):67-77.
    25. Zhang Y,? Chen Y,?Zheng J, Wang J,? Duan S, Zhang W,?Yan X* and?Zhu X* (2019).?Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat.?J Mol Cell Biol 11(5):383-394.
    26. Li G, Huang S, Yang S, Wang J, Cao J, Czajkowsky D, Shao Z, and Zhu X* (2018). abLIM1 constructs non-erythroid cortical actin networks to prevent mechanical tension-induced blebbing. Cell Discov 4:42.?
    27. Zhu L, Liu H, Chen Y, Yan X*, and Zhu X* (2018). Rsph9 is critical for ciliary radial spoke assembly and central pair microtubule stability. Biol Cell 111(2): 29-38.?
    28. Yu F, Guo S, Li T, Ran J, Zhao W, Li D, Liu M, Yan X, Yang X, Zhu X, and Zhou J* (2018). Ciliary defects caused by dysregulation of O-GlcNAc modification are associated with diabetic complications. Cell Res 29(2):171-173.
    29. Huang Y, Li T#, Ems？McClung S, Walczak C, Prigent C, Zhu X, Zhang X, and Zheng Y* (2018).Aurora A activation in mitosis promoted by BuGZ. J Cell Biol 217(1):107-116.
    30. Yan X, Zhao H and Zhu X*(2016). Production of Basal Bodies in bulk for dense multicilia formation. F1000 Research 5(F1000 Faculty Rev):1533 (doi: 10.12688/f1000research.8469.1). Review
    31. Yan X and Zhu X* (2016).PP2A in meiotic oocytes. Cell Cycle?15(15):1950-1951.?Review
    32. Zeng L, Cai C, Li S, Wang W, Li Y, Chen J, Zhu X*, Zeng YA* (2016). Essential Roles of Cyclin Y-Like 1 and Cyclin Y in Dividing Wnt-Responsive Mammary Stem/Progenitor Cells. PLoS Genet. 12(5): e1006055.
    33. Jiang H, He X, Feng D, Zhu X*, Zheng Y*(2015). RanGTP aids anaphase entry through Ubr5-mediated protein turnover. J Cell Biol. 211(1):7-18.
    34. Jiang H, Wang S, Huang Y, He X, Cui Hong, Zhu X*, and Zheng Y* (2015). Phase transitions of spindle-associated protein regulate spindle apparatus assembly Cell. 163(1):108-22.
    35. Wan Y, Zheng X, Chen H, Guo Y, Jiang H, He X, Zhu X*, and Zheng Y*(2015). Splicing function of mitotic regulators links R-loop–mediated DNA damage to tumor cell killing. J Cell Biol. 209(2), 235-46.
    36. Xu Y, Cao L, Huang S, Feng D, Zhang W, Zhu X* and Yan X* (2015). Characterization of tetratricopeptide repeat-containing proteins critical for cilia formation and function. PLoS ONE. 10(4):e0124378.
    37. Jiang H, He X, Wang S, Jia J, Wan Y, Wang Y, Zeng R, Yates III J, Zhu X*, and Zheng Y* (2014). A microtubule-associated zinc finger protein, BuGZ, regulates mitotic chromosome alignment by ensuring Bub3 stability and kinetochore targeting. Dev Cell. 28(3):268-281.
    38. Zhao H, Zhu L, Zhu Y, Cao J, Li S, Huang Q, Xu T, Huang X, Yan X* and Zhu X*(2013). The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis. Nat Cell Biol. 15(12):1434-44.
    39. Zeng L, Wan Y, Li D, Wu J, Shao M, Chen J, Hui L, Ji H,and Zhu X* (2013). The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control. J Biol Chem. 288(42):30087-93.
    40. Zhou Y, Li S, Huang Q, Xie L, Zhu X* (2013). Nanog suppresses cell migration by downregulating thymosin beta 4 and Rnd3. J Mol Cell Biol. 5(4):239-49.
    41. Yan X and Zhu X* (2013). Branched F-actin as a negative regulator of cilia formation. Exp Cell Res. 319(2):147-151
    42. Cao J, Shen Y, Zhu L, Xu Y, Zhou Y, Wu Z, Li Y, Yan X* and Zhu X* (2012). miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Nat Cell Biol. 14:697-706.
    43. Wan Y, Yang Z, Guo J, Zhang Q, Zeng L, Song W, Xiao Y, and Zhu X* (2012). Misfolded G beta is recruited to cytoplasmic dynein by Nudel for efficient clearance. Cell Res. 22: 1140-1154
    44. Wu S, Ma L, Wu Y, Zeng R, and Zhu X* (2012). Nudel is crucial for the WAVE complex assembly in vivo by selectively promoting subcomplex stability and formation through direct interactions. Cell Res. 22:1270-1284
    45. Zhao H, Zhu L, Jin Y, Ji H, Yan X* and Zhu X* (2012). miR-375 is highly expressed and possibly transactivated by ASCL1 in small cell lung cancer cells. Acta Biochim Biophys Sin. 44(2):177-82.
    46. Du J, Li Y, Zhu X* (2010). Involvement of CENP-F in histone methylation. Acta Biochim Biophys Sin. 42(3):173-6.
    47. Du J, Zhang Y, Liu Y, Li Y, and Zhu X* (2010). Involvement of Cenp-F in interphase chromatin organization possibly through association with DNA-dependent protein kinase. Acta Biochim Biophys Sin. 42: 839–846.
    48. Yan X, Shen Y, Zhu X* (2010). Live Show of Rho GTPases in Cell Migration. J Mol Cell Biol. 2: 68–69.
    49. Zhu X* (2010). Seeing the Yin and Yang in Cell Biology. Mol Biol Cell. 21: 3827–3828.
    50. Ding C, Liang X, Ma L, Yuan X and Zhu X*. (2009) Opposing effects of Ndel1 and alpha1 or alpha 2 on cytoplasmic dynein through competitive binding to Lis1. J Cell Sci. 122, 2820-2827.
    51. Zhang Q, Wang F, Cao J, Shen Y, Huang Q, Bao L and Zhu X*. (2009) Nudel promotes axonal lysosome clearance and endo-lysosome formation via dynein-mediated transport. Traffic. 10:1337-1349.
    52. Shan Y, Yu L, Li Y, Pan Y, Zhang Q, Wang F, Chen J, and Zhu X* (2009). Nudel and FAK as antagonizing strength modulators of nascent adhesions through Paxillin. PLoS Biol. 7(5): e1000116.
    53. Ma L, Tsai M-Y, Wang S, Lu B, Chen R, Yates III JR, Zhu X*, and Zheng Y* (2009). Requirement for Nudel and dynein for assembly of the lamin B spindle matrix. Nat Cell Biol. 11: 247-256.
    54. Shen Y, Li N, Wu S, Zhou Y, Shan Y, Zhang Q, Ding C, Yuan Q, Zhao F, Zeng R, Zhu X*. (2008) Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells. Dev Cell. 14, 342-353.
    55. Wang F, Zhang Q, Cao J, Huang Q, Zhu X*. (2008) The microtubule plus end-binding protein EB1 is involved in Sertoli cell plasticity in testicular seminiferous tubules. Exp Cell Res. 314, 213-226.
    56. Li Y, Yu W, Liang Y, Zhu X*. (2007) Kinetochore dynein generates a poleward pulling force to facilitate congression and full chromosome alignment. Cell Res. 17, 701-712.
    57. Liang Y, Yu W, Li Y, Yu L, Zhang Q, Wang F, Yang Z, Du J, Huang Q, Yao X, and Zhu X*. (2007) Nudel modulates kinetochore association and function of cytoplasmic dynein in M phase. Mol Biol Cell. 18, 2656-2666.
    58. Guo J, Yang Z, Song W, Chen Q, Wang F, Zhang Q, and Zhu X*. (2006) Nudel contributes to MT anchoring at the mother centriole and is involved in both dynein-dependent and independent centrosomal protein assembly. Mol Biol Cell. 17:680-9.
    59. Yang Z, Guo J, Chen Q, Du J, Ding C, and Zhu X*. (2005) Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death. Mol Cell Biol. 25, 4062-74.
    60. Zhou X, Wang R, Fan L, Li Y, Ma L, Yang Z, Yu W, Jing N, and Zhu X*. (2005) Mitosin/CENP-F as a negative regulator of activating transcription factor-4. J Biol Chem . 280, 13973-7.
    61. Liang Y, Yu W, Li Y, Yang Z, Yan X, Huang Q, and Zhu X*. (2004) Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein. J Cell Biol. 164, 557-566.
    62. Yang Z, Guo J, Li N, Qian M, Wang S, Zhu X*. (2003) Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport. Cell Res. 13, 275-283.
    63. Fan L, Yu W, Zhu X*. (2003) Interaction of Sedlin with chloride intracellular channel proteins. FEBS Lett. 540, 77-80.
    64. Yan X, Li F, Liang Y, Shen Y, Zhao X, Huang Q, and Zhu X*. (2003) Human Nudel and NudE as Regulators of Cytoplasmic Dynein in Poleward Protein Transport along the Mitotic Spindle. Mol Cell Biol. 23, 1239-50.
    65. Zhao X, Yang Z, Qian M, and Zhu X*. (2001) Interaction among subunits of human Arp2/3 complex: p20-Arc as the hub. Biochem Biophy Res Commun. 280, 513-517.
    66. Yan X., Zhao X, Qian M, Guo N, Gong X, and Zhu X*. (2000) Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I. Biochem J. 345, 749-757.
    67. Zhu X*. (1999) Structural requirements and dynamics of mitosin-kinetochore interaction in M phase. Mol Cell Biol. 19, 1016-1024.
    68. Zhu X*, Ding L, and Pei G (1997). Carboxyl terminus of mitosin is sufficient to confer spindle pole localization. J Cell Biochem. 66:441-449.
    獲獎(jiǎng)及榮譽(yù)：
    研究組成員：

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