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1998年本科畢業(yè)于南開大學(xué)，2003年畢業(yè)于中國科學(xué)院上海生命科學(xué)研究院生物化學(xué)與細(xì)胞生物學(xué)研究所，獲理學(xué)博士學(xué)位。2003-2012年先后在美國Scripps研究所和哈佛大學(xué)公共衛(wèi)生學(xué)院進(jìn)行博士后研究并受美國白血病淋巴瘤協(xié)會(huì)資助，2009年入選哈佛大學(xué)公共衛(wèi)生學(xué)院Yerby Fellow，2012年獲聘康納爾大學(xué)和紐約州立大學(xué)布法羅分校Tenure Track助理教授職位，2012年8月加入中國科學(xué)院生物化學(xué)與細(xì)胞生物學(xué)研究所，任研究員、研究組長、博士生導(dǎo)師。獲國家自然科學(xué)基金委杰出青年科學(xué)基金、優(yōu)秀青年基金，國家海外高層次人才計(jì)劃（青年類）資助，主持國家自然科學(xué)基金委重大項(xiàng)目、重點(diǎn)項(xiàng)目，國家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃（973計(jì)劃）課題，中國科學(xué)院戰(zhàn)略性先導(dǎo)科技專項(xiàng)課題等。擔(dān)任國際華人骨研學(xué)會(huì)（ICMRS）董事會(huì)董事、中國生物工程學(xué)會(huì)轉(zhuǎn)化醫(yī)學(xué)專業(yè)委員會(huì)副主任委員、中華醫(yī)學(xué)會(huì)骨科學(xué)分會(huì)組織工程與再生醫(yī)學(xué)青年組組長、中國骨質(zhì)疏松與骨礦鹽疾病分會(huì)基礎(chǔ)組常委、中國老年醫(yī)學(xué)會(huì)骨質(zhì)疏松分會(huì)創(chuàng)新與轉(zhuǎn)化專委會(huì)常委等。

運(yùn)動(dòng)系統(tǒng)功能性干細(xì)胞包括骨膜干細(xì)胞、生長板干細(xì)胞、骨髓間充質(zhì)干細(xì)胞、關(guān)節(jié)軟骨干細(xì)胞、肌腱干細(xì)胞、肌肉干細(xì)胞等。運(yùn)動(dòng)系統(tǒng)功能性干細(xì)胞具有多能性和自我更新能力，在組織發(fā)育、穩(wěn)態(tài)維持、疾病和衰老等過程中起重要作用。運(yùn)動(dòng)系統(tǒng)功能性干細(xì)胞向不同組織細(xì)胞的分化受到多種遺傳因素和表觀遺傳因素的影響，并受多種信號途徑調(diào)控。調(diào)控因素的異常將導(dǎo)致多種疾病，包括先天性發(fā)育畸形、運(yùn)動(dòng)系統(tǒng)退行性疾病如骨質(zhì)疏松癥、骨性關(guān)節(jié)炎以及肌腱疾病等。

研究組通過綜合運(yùn)用空間轉(zhuǎn)錄組測序、單細(xì)胞測序、譜系示蹤等多種研究手段來鑒定運(yùn)動(dòng)系統(tǒng)新型干細(xì)胞。已建立了間充質(zhì)干細(xì)胞向多種細(xì)胞分化的體外高通量篩選系統(tǒng)，研究干細(xì)胞增殖分化的分子機(jī)制及多種相關(guān)疾病的致病機(jī)理，并通過分子遺傳學(xué)手段建立了骨骼早衰、力學(xué)感知失調(diào)、關(guān)鍵干細(xì)胞穩(wěn)態(tài)失調(diào)等多種動(dòng)物模型，模擬骨質(zhì)疏松、骨關(guān)節(jié)炎、骨折等常見骨科疾病，圍繞骨骼系統(tǒng)的受力、衰老與功能性干/前體細(xì)胞等關(guān)鍵科學(xué)問題，在骨科基礎(chǔ)研究領(lǐng)域取得了多項(xiàng)創(chuàng)新性研究成果。

實(shí)驗(yàn)室近期研究方向包括：

1）鑒定運(yùn)動(dòng)系統(tǒng)功能性干細(xì)胞，研究其參與損傷修復(fù)的命運(yùn)轉(zhuǎn)歸和調(diào)控機(jī)制。

2）研究機(jī)械力對間充質(zhì)干細(xì)胞/運(yùn)動(dòng)系統(tǒng)功能性干細(xì)胞的調(diào)控及其分子機(jī)制。

3）研究間充質(zhì)干細(xì)胞/運(yùn)動(dòng)系統(tǒng)功能性干細(xì)胞的衰老與疾病的關(guān)聯(lián)及分子機(jī)制。

1. Ren Q, Xing W, Jiang B, Feng H, Hu X, Suo J, Wang L*, Zou W*. (2025) Tenascin-C promotes bone regeneration via inflammatory macrophages. Cell Death and Differentiation. 32(4): 763-775.
2. Wang L^#*, Ren Q^#, Chen S^#, Lou L, Hu X, Xing W, Suo J, Sun J, Greenblatt M, Feng H, Zou W*. (2025) Piezo1 balances the osteogenic-tenogenic plasticity of periosteal progenitor cells through the YAP pathway. Cell Reports. 44(5): 115630.
3. Xing W^#, Feng H^#*, Jiang B, Gao B, Liu J, Xie Z, Zhang Y, Hu X, Sun J, Greenblatt M, Zhou B*, Zou W*. (2024) Identification of a Periosteal Itm2a-expressing Skeletal Stem Cell Contributing to Bone Fracture Healing. Journal of Clinical Investigation. 134(17): e176528.
4. Liu Y^#, Tang X^#, Shu H^#, Zou W*, Zhou B*. (2024) Fibrous periosteum repairs bone fracture and maintains the healed bone throughout mouse adulthood. Developmental Cell. 59(9): 1192-1209.e6.
5. Wang L#, You X#, Ruan D#, Shao R, Dai H, Shen W, Xu G, Liu W, Zou W*. (2022) TET enzymes regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes. Nature Communications. 13(1):4709.
6. Gao B#, Jiang B#, Xing W, Xie Z, Luo Z*, Zou W*. (2022) Discovery and application of postnatal nucleus pulposus progenitors essential for intervertebral disc homeostasis and degeneration. Advanced Science. 9(13): e2104888.
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8. Wang L, You X, Zhang L, Zhang C, Zou W*. (2022) Mechanical regulation of bone remodeling. Bone Research. 10(1): 16.
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10. Feng H#, Xing W#, Han W#, Sun J, Kong M, Gao B, Yang Y, Yin Z, Chen X, Zhao Y, Bi Q, Zou W*. (2020) Tendon-derived cathepsin K-expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification. Journal of Clinical Investigation. 130(12): 6354-6365.
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12. Suo J#, Feng X#, Li J, Wang J, Wang Z*, Zhang L*, Zou W*. (2020) VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited RUNX2 transcription. Science Advances. 6(43): eaba4147.
13. Wang L, You X, Lotinun S, Zhang L, Wu N, Zou W*. (2020) Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk. Nature Communications. 11: 282.
14. Han Y, Feng H, Sun J, Liang X, Wang Z, Xing W, Dai Q, Yang Y, Han A, Wei Z, Bi Q, Ji H, Kang T *, Zou W*. (2019) Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation. Journal of Clinical Investigation. 129: 1895-1909.
15. Bai M, Han Y, Wu Yu, Liao J, Li L, Wang L, Li Q, Xing W, Chen L, Zou W*, Li J*. (2019) Targeted genetic screening in mice through haploid embryonic stem cells identifies critical genes in bone development. PLoS Biology. 17: e3000350.
16. Wang L, Niu N, Li L, Shao R, Ouyang H, Zou W*. (2018) H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells. PLoS Biology. 16: e2006522.
17. Han Y, You X, Xing W, Zhang Z, Zou W*. (2018) Paracrine and endocrine actions of bone-the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts. Bone Research. May 24; 6:16.
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20. Xu Z, Greenblatt M, Yan G, Feng H, Sun J, Lotinun S, Brady N, Baron R, Glimcher L, Zou W*. (2017) SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts. Nature Communications 8:14570.
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24. Zou W, Chen X., Shim J, Huang Z, Brady N, Hu D, Drapp R, Sigrist K, Glimcher L, Jones D*. (2011) The E3 ubiquitin ligase Wwp2 regulates craniofacial development through monoubiquitination of Goosecoid. Nature Cell Biology. 13: 59–65.
25. Zou W#, Greenblatt M#, Shim J, Kant S, Zhai B, Brady B, Hu D, Gygi S, Davis R, Jones D, Glimcher L*. (2011) MLK3 regulates bone development downstream of the Faciogenital Dysplasia protein FGD1. Journal of Clinical Investigation. 121: 4383-92.
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